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Research conducted or supported by the Department of Defense (DoD), including its separate components (i.e., the Army, Navy, Air Force and Marine Corps) requires compliance with additional federal regulations, directives and instructions. The DoD has adopted 32 CFR 219, a version of the Common Rule that mirrors 45 CFR 46. The Department of Defense Instruction 3216.02 (DoDI 3216.02) establishes policy and assigns responsibilities for implementation of 32 CFR 219 in protecting human subjects in DoD-supported research. The University of Iowa, its IRBs and investigators involved in DoD research must be knowledgeable about these obligations in order to adhere to them. The Education and Compliance Program has implemented a program to monitor the adherence with the additional requirements for DoD-supported research.